对一株分离自昆虫铜绿金龟子幼虫肠道的链霉菌Streptomyces sp.BCa1的次生代谢产物进行化学研究。采用摇瓶发酵,并用柱色谱技术对该链霉菌的次生代谢产物进行分离纯化和利用光谱分析进行结构鉴定。结果从菌株Streptomyces sp.BCa1的发酵液中分离获得1个具有Hsp90蛋白抑制活性的格尔德霉素(geldanamycin)以及2个萘醌型大环内酯类化合物。所有化合物均为首次从昆虫来源的链霉菌中发现,且格尔德霉素为其主要产物,表明昆虫来源的放线菌具有良好的开发前景。 A secondary metabolite of Streptomyces sp. BCa1, isolated from the gut of insect larvae of the green chafer, was studied chemically. The fermentation was carried out by shake flask, and the secondary metabolites of Streptomyces were isolated and purified by column chromatography and identified by spectroscopic analysis. As a result, one geldanamycin having Hsp90 protein inhibitory activity and two naphthoquinone macrolide compounds were isolated from the fermentation broth of the strain Streptomyces sp. BCa1. All compounds were found for the first time from insect-derived Streptomyces, and geldanamycin as the main product, indicating that insect-derived actinomycetes have good prospects for development.