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神经母细胞瘤 (neuroblastoma ,NB)易形成临床耐药 ,其中多药耐药 (mul tidrugresistance ,MDR)是一种重要类型 ,即用单个细胞毒药物治疗后 ,肿瘤细胞对其它功能和结构都不相关的药物形成交叉耐药。本文主要从其细胞机制方面进行阐述。1 药物运输的改变肿瘤细胞可以通过细胞膜
Neuroblastoma (NB) is prone to become clinically resistant, of which mul tidrug resistance (MDR) is an important type of tumor that has no effect on other functions and structures after treatment with a single cytotoxic drug Related drugs form cross-resistance. This article mainly elaborates on its cellular mechanism. 1 Drug Transport Changes Tumor cells can pass through the cell membrane