论文部分内容阅读
目的:观察低分子肝素钙+丹参治疗早发型重度子痫前期对围产结局的影响。方法:选取孕龄26～34周重度子痫前期患者116例,自愿分为A组32例(硫酸镁常规治疗),B组28例(硫酸镁+低分子肝素钙组),C组30例(硫酸镁+丹参组),D组26例(硫酸镁+低分子肝素钙+丹参组)。对比4组在延长孕龄时间、脐动脉S/D比值、羊水指数、胎盘重量、新生儿体重、Apgar评分的差异。结果:D组延长孕龄时间最长,脐动脉S/D比值下降,羊水量,新生儿体质量均增加,新生儿窒息率下降,与其他3组对比差异有统计学意义,P<0.05;胎盘重量增加,与A组对比差异有统计学意义,P<0.05;与B、C组对比差异无统计学意义,P>0.05。结论:低分子肝素钙联合丹参治疗早发型重度子痫前期,可改善胎盘功能,延长孕龄,明显改善新生儿预后,二者联合应用有协同作用。
Objective: To observe the effect of low molecular weight heparin calcium and salvia miltiorrhiza on perinatal outcome in patients with early-onset severe preeclampsia. Methods: One hundred and sixty-six patients with severe preeclampsia aged 26-34 weeks were enrolled. A group of 32 patients were randomly divided into group A (conventional treatment with magnesium sulfate), group B (n = 28), magnesium sulfate + low molecular weight heparin group (Magnesium sulfate + Danshen group), D group 26 cases (magnesium sulfate + low molecular weight heparin + Danshen group). The differences between 4 groups in prolonging gestational age, umbilical artery S / D ratio, amniotic fluid index, placental weight, neonatal body weight, Apgar score were compared. Results: D group prolonged gestational age the longest, umbilical artery S / D ratio decreased, amniotic fluid volume, newborn body mass increased, neonatal asphyxia decreased, compared with the other three groups, the difference was statistically significant, P <0.05; The weight of placenta increased significantly compared with that of group A (P <0.05). There was no significant difference between group B and C (P> 0.05). Conclusion: Low molecular weight heparin combined with Salvia miltiorrhiza for early-onset severe preeclampsia can improve the placental function, prolong the gestational age, and significantly improve the prognosis of neonates. The combination of the two drugs has synergistic effects.