该团队之前研究报道由敲除内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)~(-/-)基因(eNOS~(-/-)KO)的高血压母鼠所生的杂交子代小鼠部分缺乏eNOS基因可发生高血压。本研究推测,这些子代小鼠若以高脂喂养将会发生代谢调节改变而增加其发展为代谢综合征的风险。方法:通过eNOS~(-/-)KO和野生型小鼠(eNOS~(+/+)WT)杂交生成杂合的子 The team previously reported that hybrids produced by hypertensive dams that knocked out the endothelial nitric oxide synthase (eNOS) ~ (- / -) gene (eNOS ~ (-) - KO) Partial generation of mice lacking eNOS gene can occur high blood pressure. This study speculated that if these offspring mice will be fat-fed high-fat metabolic regulation will change and increase their risk of developing metabolic syndrome. Methods: Hybridized eNOS ~ (- / -) KO and wild-type mice (eNOS ~ (+ / +) WT)