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目的探讨ILK和PKB在正常卵巢、卵巢良性肿瘤、卵巢交界性肿瘤、卵巢癌组织中的表达及其临床意义。方法采用免疫组织化学SP染色检测正常卵巢组织、良性卵巢肿瘤、交界性肿瘤、卵巢癌中ILK和P-PKB的表达。结果ILK和P-PKB蛋白在卵巢癌中表达率明显高于良性肿瘤中的表达率(P<0.05);ILK和P-PKB蛋白表达与卵巢癌患者的年龄、组织学类型无相关,(P>0.05);与临床分期、有无腹水及淋巴转移显著相关,(P<0.01)。上皮性卵巢癌中ILK表达与P-PKB蛋白表达显著正相关,(r=0.739,P<0.01)。结论ILK、P-PKB蛋白的表达与卵巢上皮性肿瘤的发生、发展密切相关。
Objective To investigate the expression and clinical significance of ILK and PKB in normal ovary, benign ovarian tumor, borderline ovarian tumor and ovarian cancer. Methods Immunohistochemical SP staining was used to detect the expression of ILK and P-PKB in normal ovarian tissue, benign ovarian tumor, borderline tumor and ovarian cancer. Results The expression of ILK and P-PKB in ovarian cancer was significantly higher than that in benign tumors (P <0.05). The expressions of ILK and P-PKB were not correlated with the age and histological type of ovarian cancer (P > 0.05). There was a significant correlation between clinical stage and presence of ascites and lymphatic metastasis (P <0.01). ILK expression in epithelial ovarian cancer was positively correlated with P-PKB protein expression (r = 0.739, P <0.01). Conclusion The expressions of ILK and P-PKB are closely related to the occurrence and development of ovarian epithelial tumor.