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目的:探索巴豆配伍桔梗是否具有“减毒”作用及其作用机制。方法:以动物死亡状态及半数致死量(LD50)为评价指标,比较巴豆配伍不同剂量比的桔梗前后的动物中毒情况;通过测定比较巴豆配伍桔梗的不同剂量比下巴豆苷含量,从化学成分角度揭示巴豆配伍桔梗“减毒”作用机制。结果:巴豆配伍不同剂量比桔梗,其毒性反应均减小,且以1∶3剂量比值下LD50及其95%可行限抬高最多;同时配伍不同剂量比桔梗后巴豆苷含量呈现“抛物线”式变化,在1∶3剂量比时巴豆苷含量降低最多(32.57%)。结论:巴豆配伍桔梗(1∶3)剂量比值为其减毒作用最佳比值,可能与其减少了游离态巴豆苷含量有关。
Objective: To explore whether Croton mixed Platycodonis has “attenuated” effect and its mechanism. Methods: The animals were killed and the lethal dose (LD50) was taken as the evaluation index to compare the toxicity of croton with different dose ratios of Campanulaceae before and after treatment. By comparing the different dosages of Croton with Campanulaceae, Reveal croton compatibility Campanulaceae “attenuate ” mechanism of action. Results: Compared with Platycodon, the toxic responses of Croton to different doses of Platycodon were all reduced, and LD50 and its 95% limit of maximal expiration were all increased at a dose ratio of 1: 3. At the same time, compared with Platycodon, "Changes in the ratio of 1: 3 when the dose of cotinine to reduce the most (32.57%). CONCLUSION: The dose ratio of croton and Campanulaceae (1: 3) is the best ratio of attenuated effect, which may be related to the decrease of the content of free croton glycosides.