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目的 探讨静脉滴注免疫球蛋白 (IVIG)对川崎病患儿细胞免疫 (红细胞免疫及T细胞亚群 )功能的影响及其预防冠状动脉损害的作用机理。方法 T细胞亚群采用S P一步法 ,红细胞免疫活性及其调节因子测定用刘景田法。测定 37例川崎病患儿急性期及恢复期细胞免疫功能的变化。结果 川崎病患儿急性期红细胞C3b受体花环率 (RBC·C3bRR)下降 ,免疫复合物花环率 (ICRR)升高 ,促进因子 (E)活性降低 ,抑制因子 (I)升高 ,E/I降低 ,CD3、CD4下降 ,CD8升高 ,CD4 /CD8下降 ,与对照组比较有显著差异 (P <0 .0 1 )。经IVIG治疗后RBC·C3bR、促进因子 (E)回升 ,ICRR抑制因子 (I)下降 ,CD3、CD4回升 ,CD8下降 ,CD4 /CD8回升 ,临床症状明显改善。结论 细胞免疫功能改变参与了川崎病的发病 ,IVIG可能与提供抗体抑制免疫反应 ,减少血管炎症反应有关 ,IVIG能改善川崎病急性期炎症及预防冠状动脉损害
Objective To investigate the effect of intravenous immunoglobulin (IVIG) on cellular immunity (erythrocyte immunity and T cell subsets) in children with Kawasaki disease and its mechanism of preventing coronary artery lesion. Methods T cell subsets using S P one-step method, erythrocyte immune activity and its regulatory factor determination with Liu Jingtian method. The changes of cellular immune function in 37 children with Kawasaki disease at acute and convalescent stage were determined. Results The RBC · C3bRR of erythrocyte erythrocytes in children with acute Kawasaki disease were decreased, and the ICRR of immune complex increased, the activity of promoting factor (E) decreased, the inhibitory factor (I) increased and the ratio of E / I CD3, CD4, CD8, CD4 / CD8 decreased significantly compared with the control group (P <0.01). After IVIG treatment, RBC · C3bR, promoting factor (E) recovery, ICRR inhibitor (I) decreased, CD3, CD4 rise, CD8 decreased, CD4 / CD8 recovery, clinical symptoms improved significantly. Conclusions The change of cellular immune function is involved in the pathogenesis of Kawasaki disease. IVIG may be related to providing antibody to suppress immune response and reducing vascular inflammation. IVIG can improve Kawasaki disease in acute phase and prevent coronary artery injury