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目的探讨益母草注射液预防产后出血的疗效和安全性。方法符合纳入标准的产妇120例随机分为三组,其中益母草组40例;益母草联合缩宫素组41例;缩宫素组39例。观察胎盘娩出后及产后各时段阴道出血量;产后24 h内出血发生率;产前、产后血红蛋白差值。结果产后12 h时段A、B组阴道出血量少于C组(P<0.05),其余各时段阴道出血量差异无统计学意义(P>0.05)。产后24 h内出血发生率差异无统计学意义(P>0.05)。产前、产后血红蛋白差值差异无统计学意义(P>0.05)。各组均未发生不良反应。结论益母草有缓慢但持续的缩宫效果,和缩宫素联合应用效果更好,药物安全性良好。
Objective To investigate the efficacy and safety of Motherwort Injection in preventing postpartum hemorrhage. Methods A total of 120 maternal women who met the inclusion criteria were randomly divided into three groups, 40 for motherwort, 41 for motherwort combined with oxytocin and 39 for oxytocin. Observe the placenta after delivery and postpartum vaginal bleeding at various times; postpartum hemorrhage within 24 h incidence; prenatal and postnatal hemoglobin difference. Results The amount of vaginal bleeding in groups A and B was less than that in group C at 12 h postpartum (P <0.05). There was no significant difference in the amount of vaginal bleeding among the other groups (P> 0.05). No significant difference was found in the incidence of hemorrhage within 24 hours after delivery (P> 0.05). The difference of prenatal and postnatal hemoglobin was not statistically significant (P> 0.05). No adverse reactions occurred in all groups. Conclusion Motherwort has a slow but sustained contraction of the effect, and oxytocin combination effect is better, good drug safety.