本文对我国研制的抗孕-53,进行口服与针剂用药的对比试验。显示针剂对新西兰兔、大小白鼠均有抗早孕的效果,而且用药量低于口服药。此外,针剂对孕兔、假孕兔和早孕大鼠的黄体功能均有明显的抑制作用,使血浆孕酮水平明显降低,并出现溶黄体现象。在临床探索性研究中表明抗孕-53对抗早孕也有部分效果,而催经的效果更明显,作为长效避孕针剂则是今后研究的方向。 This article developed in our country anti-pregnancy -53, oral and injections contrast test. The injection shows New Zealand rabbit, white mice have anti-pregnancy effect, and the dosage is lower than the oral medication. In addition, the injection of luteinizing effect on pregnant rabbits, fake pregnant rabbits and early pregnancy rats were significantly inhibited, the plasma progesterone levels were significantly reduced, and the emergence of luteal phenomenon. In clinical exploratory studies have shown that there is some effect of anti-pregnancy -53 against early pregnancy, and the effect of reminders is more obvious as a long-acting contraceptives is the future direction of the study.