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探讨结肠溶口服胸腺肽对环孢素Ａ免疫抑制小鼠免疫功能的影响。方法：采用环孢素Ａ制备免疫低下的ＢＡＬＢ／ｃ小鼠模型，口服胸腺肽灌胃［０．３～３．０ｍｇ／（ｋｇ· ｄ）］，以其注射剂作阳性对照，分别作非特异性免疫、体液免疫：并用细胞毒试验作胸腺Ｔ细胞亚群的细胞免疫测定。结果：试验表明不明显影响前２项免疫（Ｐ＞０．０５）；但可有意义地促进胸腺Ｔ细胞亚群Ｔｎｙ－Ｉ、Ｌ３Ｔ４水平的提升（Ｐ＜０．０５或Ｐ＜０．０１）；灌服剂量与Ｔｈｙ－１、Ｌ３Ｔ４水平的相关分析呈正相关。结论：提示口服和注射给药一样，均具有特异地增强和调节Ｔ细胞免疫功能的作用和效果。
To investigate the effect of oral administration of recombinant oral thymosin on immune function of immunosuppressive mice induced by cyclosporin A Methods: Immunosuppressive BALB / c mouse model was established by cyclosporin A and oral administration of thymosin (0.3 ~ 3.0 mg / (kg · d)] was given. The injection was used as a positive control for non-specific immunization , Humoral immunity: and cytotoxicity test for thymic T cell subsets of cellular immunoassay. Results: The results showed that the first two immunizations did not affect significantly (P> 0.05), but could significantly promote the increase of T lymphocyte subsets Tym-I and L3T4 (P <0.05 or P <0.01) ). There was a positive correlation between dose of gavage and Thy-1 and L3T4 levels. Conclusion: It is suggested that both oral administration and injection administration have the same effect and effect of specifically enhancing and regulating T cell immune function.