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我们发现,正常小鼠在胃肠道线虫Nippostrongylus brasiliensis后蚴接种(PI)12天时即排除感染,而在Scid/Scid小鼠此感染至少持续到接种后47天。正常小鼠可患显著的肠肥大细胞症,而Scid/Scid小鼠则不患此症。若正常小鼠和Scid/Scid小鼠骨细胞培养基中含有适宜的巨细胞生长因子,则巨细胞可在其中生长。用ConA激活的正常小鼠脾细胞(CM)调整过的培养基,在体外,可辅助正常小鼠骨髓中祖细胞而产生巨细胞的生长;但用Scid/Scid CM调整的培养基,则不能有效地辅助此类巨细胞生长。由上可见,Scicl/Scicl小鼠尽管具有巨细胞的祖细胞,但由于其可能缺乏产生各类巨细胞生长因子所需的T细胞,而不发生肥大细胞病。
We found that normal mice ruled out infection 12 days after the gastrointestinal nematode Nippostrongylus brasiliensis cecropia (PI), whereas infection in Scid / Scid mice lasted at least until 47 days after inoculation. Normal mice can have significant intestinal mastocytosis, whereas Scid / Scid mice do not. If the normal mouse and Scid / Scid mouse osteoblast culture medium contains the appropriate giant cell growth factor, the giant cells can grow in it. ConA-activated normal mouse splenocytes (CM) -transformed media produced giant cell growth in vitro in vitro in progenitor cells from normal mouse bone marrow; however, media conditioned with Scid / Scid CM did not Effectively assist in the growth of such giant cells. From the above, Scicl / Scicl mice, despite having giant cell progenitor cells, do not develop mast cell disease because they may lack the T cells needed to produce various types of giant cell growth factors.