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鼻咽癌是中国、格陵兰和地中海地区等国家最常见的肿瘤。该病的原发病灶常难以发现,又易发生转移,且与头颈部其他肿瘤难以鉴别。现知EB 病毒与淋巴样和非淋巴样肿瘤相关,但与鳞状细胞病灶的关系鲜见报道,鼻咽癌细胞中存在EB 病毒基因,但转移灶是否携带病毒仍属未知。作者探讨EB 病毒与转移至颈部的鼻咽癌之间的关系,用多聚酶链反应(PCR)检测EB 病毒阳性细胞,并评价该法在诊断鼻咽癌上的价值。检测标本为:用细针抽吸的颈部转移性鳞状细胞癌标本15份,肿瘤病人淋巴结活检标本26份,对照组包括取自各种头颈部肿瘤病人但无病变的淋巴
Nasopharyngeal carcinoma is the most common tumor in China, Greenland and the Mediterranean. The disease is often difficult to find the primary lesion, but also prone to metastasis, and other head and neck cancer is difficult to identify. The EB virus is known to be associated with both lymphoid and non-lymphoid tumors, but few reports have shown any relationship with squamous cell lesions. EBV genes are present in nasopharyngeal carcinoma cells, but whether the metastases carry the virus remains unknown. The author explores the relationship between Epstein-Barr virus (EB) and nasopharyngeal carcinoma (NPC) transferred to the neck. The Epstein-Barr virus positive cells were detected by polymerase chain reaction (PCR) and the value of this method in the diagnosis of nasopharyngeal carcinoma was evaluated. The test specimens were: 15 specimens of cervical metastatic squamous cell carcinoma with fine needle suction, 26 specimens of lymph node biopsy in tumor patients, and the control group included lymphoid lesions from various head and neck cancer patients without lesions