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目的评价脑卒中高危人群脑安胶囊重点预防措施的人群实施效果。方法从上海市南汇区全区696558人群选择≥35岁具有脑卒中危险因素暴露者进行脑血管血液动力学检测,筛选出脑血管血液动力学指标积分值低于70分的脑卒中高危个体18271例作为干预对象。根据知情同意的原则,在同样接受一般干预的基础上,将10313例接受“脑安胶囊”干预者作为重点干预组,另7958例未接受脑安胶囊干预者作为一般干预组。随访监测干预后脑卒中的发病和死亡情况,评价干预策略实施3年后的预防效果。结果重点干预组脑卒中发病率显著低于一般干预组(P<0.01),男性下降53.8%,相对危险度为0.46(0.33～0.64);女性下降58.4%,相对危险度为0.39(0.30～0.50)。多因素分析logistic回归分析显示,被筛选进入方程的因素分别为高血压病史、脑血管血液动力学指标积分值、年龄、性别和脑安胶囊干预,其中脑安胶囊干预的相对危险度为0.41,在诸因素中作用最强。结论干预策略实施3年后,脑安胶囊重点干预组的脑卒中发病率显著低于一般干预组,脑安胶囊干预是高危个体脑卒中发病最强的影响因素。
Objective To evaluate the effect of the population-based preventive measures on brain-capsule in high-risk stroke patients. Methods A total of 696,558 people in Nanhui district of Shanghai were enrolled in this study. Cerebral hemo-hemodynamics was measured in 35-year-old adults with stroke risk factors. 18,271 individuals with high risk of stroke who scored less than 70 points in cerebral vascular hemodynamics were screened out. As an intervention target. According to the principle of informed consent, on the basis of the same general intervention, 10313 patients receiving “brain capsule” as the key intervention group, and 7958 patients without brain capsule intervention as the general intervention group. Follow-up monitoring of stroke morbidity and mortality after intervention, evaluation of intervention strategies to implement the preventive effect after 3 years. Results The incidence of stroke in the key intervention group was significantly lower than that in the general intervention group (P <0.01). The relative risk was 0.46 (0.33 ~ 0.64) in the male and 58.4% in the male, the relative risk was 0.39 (0.30 ~ 0.50 ). Multivariate analysis Logistic regression analysis showed that the factors screened into the equation were the history of hypertension, the integral value of cerebrovascular hemodynamics index, age, sex and the dosage of Na’an Capsule. The relative risk of Naobao Capsule intervention was 0.41, Among the most influential factors. Conclusions After 3 years of intervention strategy, the incidence of stroke in the key intervention group of Na’an Capsule group is significantly lower than that of the general intervention group. The intervention of Na’an Capsule is the strongest factor in the stroke incidence in high-risk individuals.