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目的:通过检测胰腺癌病人的静息能量消耗(REE)和血浆细胞因子,探讨两者间的关系。方法:用间接能量测定法检测34例诊断为胰腺癌的病人(试验组)和同期30例腹股沟疝病人(对照组)的REE,测定血浆细胞因子(TNF-α、IL-6、IL-1),将REE和细胞因子做相关性分析。结果:试验组病人REE非常显著地高于对照组,为(1 449.03±315.47)kcal vs(1 344.67±128.52)kcal,P<0.01;呼吸商(RQ)非常显著地低于对照组,为(0.81±0.06)vs(0.88±0.08),P<0.01;细胞因子TNF-α和IL-6非常显著地高于对照组(P<0.01),而IL-1两组无显著性差异。胰腺癌病人血浆TNF-α与REE有非常显著的正相关性(P<0.01);IL-6与REE有显著相关性(P<0.05)。结论:胰腺癌病人REE显著增加,血浆细胞因子TNF-α和IL-6显著升高。胰腺癌病人REE的升高可能与细胞因子TNF-α和IL-6的升高有一定的相关性。
OBJECTIVE: To investigate the relationship between resting energy expenditure (REE) and plasma cytokines in pancreatic cancer patients. Methods: 34 patients with pancreatic cancer (experimental group) and 30 patients with inguinal hernia (control group) were enrolled in this study. The plasma levels of TNF-α, IL-6 and IL-1 ), REE and cytokines do correlation analysis. Results: The REE of the experimental group was significantly higher than that of the control group (1 449.03 ± 315.47 kcal vs (1 344.67 ± 128.52) kcal, P <0.01). The respiratory quotient (RQ) was significantly lower than that of the control group 0.81 ± 0.06) vs (0.88 ± 0.08), P <0.01. The levels of TNF-α and IL-6 in cytokines were significantly higher than those in control group (P <0.01). There was no significant difference between the two groups. There was a significant positive correlation between plasma TNF-α and REE in patients with pancreatic cancer (P <0.01). There was a significant correlation between IL-6 and REE (P <0.05). Conclusion: The REE of pancreatic cancer patients increased significantly, and the levels of plasma cytokines TNF-α and IL-6 were significantly increased. Elevated pancreatic cancer patients with REE may be cytokines TNF-α and IL-6 increased a certain degree of correlation.