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利培酮(RIS)与枸橼酸、乳精和甘露醇混合后用湿法制粒,所得颗粒用7 mm冲压制成片剂后再用含4.5%乙酸纤维素的95%丙酮(含聚乙二醇作增塑剂)包衣,经激光打孔后得到具有350μm释药小孔的载药有孔渗透泵(RIS-EOP)片剂。通过调节处方中枸橼酸用量可增加RIS的溶解度。考察了渗透剂和
Risperidone (RIS) was mixed with citric acid, lactose and mannitol and granulated by wet granulation. The resulting granules were punched into tablets at 7 mm and then treated with 95% acetone containing 4.5% cellulose acetate Diol as a plasticizer) and laser-blown to give a drug-loaded porous osmotic pump (RIS-EOP) tablet having a 350 μιη drug delivery orifice. By adjusting the amount of citric acid prescription can increase the solubility of RIS. Investigated the penetrant and