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以成年雄性健康大鼠18只分成染尘组和用葡萄糖酸锌(ZincGluconane)治疗A组、治疗B三组。各组大鼠均气管内注入 50mg石英粉尘。用葡萄糖酸锌治疗A和治疗B组自染尘后第四日起灌胃给药,每天二次,每次2ml,每周六天。治疗A组每次灌入葡萄糖酸锌50mg,治疗B组每次灌入10mg。染尘后二个月时将动物处死。 染尘组大鼠的肺门淋巴结湿重、全肺干重和全肺胶原蛋白含量分别是0.45±0.11g、1.33±0.33g、127.6±52.6mg,葡萄糖酸锌治疗A
18 adult male healthy rats were divided into dust group and zinc gluconate (ZincGluconane) treatment group A, treatment B three groups. Each group of rats were intratracheal injection of 50mg quartz dust. Treatment with zinc gluconate A and treatment Group B from the fourth day after the dosing dust gavage, twice daily, each 2ml, six days a week. Treatment A group were infused with zinc gluconate 50mg, treatment group B each infused 10mg. Animals were sacrificed two months after the dying. Damp group rats hilar lymph node wet weight, total lung dry weight and total lung collagen content were 0.45 ± 0.11g, 1.33 ± 0.33g, 127.6 ± 52.6mg, zinc gluconate treatment A