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Vidarabine(adenine arabinoside,阿糖腺嘌呤核甙)是一种合成的有抗病毒活性的嘌呤核甙,能对抗多种DNA病毒和某些RNA肿瘤病毒。相对地无毒性,可能不会影响细胞或体液免疫功能,而且不会引起胎儿畸形。其作用方式可能是阻碍病毒的DNA多聚酶活性,从而抑制病毒的复制。本文报告用Vidarabine治疗4例经肝活检证实的HBsAg阳性慢性肝病患者,年龄分别为23、28、31和45岁,病程为6个月至2年。3例为慢性活动性
Vidarabine (adenine arabinoside) is a synthetic antiviral activity of purine nucleosides against various DNA viruses and certain RNA oncolytic viruses. Relatively non-toxic, may not affect cellular or humoral immune function, and will not cause fetal deformity. Its mode of action may be hindered the DNA polymerase activity of the virus, thereby inhibiting the replication of the virus. This article reports the use of Vidarabine in the treatment of 4 patients with HBsAg-positive chronic liver disease confirmed by liver biopsy, with an age of 23, 28, 31, and 45 years, respectively, and a duration of 6 months to 2 years. 3 cases of chronic activity