目的观察多西紫杉醇联合顺铂治疗晚期乳腺癌的疗效及不良反应。方法晚期乳腺癌患者35例,予多西紫杉醇联合顺铂方案化疗,2周期后评价疗效。结果35例中总有效率为54.3%,不良反应主要为骨髓抑制、脱发、消化道反应,但均可耐受,无化疗相关死亡。结论多西紫杉醇为主的联合化疗方案治疗晚期乳腺癌疗效较好,不良反应可耐受。 Objective To observe the efficacy and adverse reactions of docetaxel combined with cisplatin in the treatment of advanced breast cancer. Methods Twenty-five patients with advanced breast cancer were treated with docetaxel plus cisplatin chemotherapy and evaluated after 2 cycles. Results The total effective rate was 54.3% in 35 cases. The main adverse reactions were myelosuppression, alopecia, and gastrointestinal reactions, but all were tolerable without chemotherapy-related death. Conclusions Docetaxel-based combination chemotherapy is effective in treating advanced breast cancer, and adverse reactions are tolerable.