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以玉米蛋白为壁材,白藜芦醇为模型药物,采用超临界CO2抗溶剂法制备负载白藜芦醇的玉米蛋白纳米粒,考察了过程参数压力、温度以及芯材质量比对白藜芦醇在纳米粒中负载量的影响。用紫外光谱分析、扫描电镜、X射线衍射分析等方法对样品进行了表征,并且对释放度进行研究。结果表明,随着超临界CO2压力的增加,白藜芦醇的负载量降低;随着温度和芯材质量比的增加,白藜芦醇的负载量升高。玉米蛋白和白藜芦醇形成Matrix结构,纳米粒为均匀球形颗粒。释放度实验显示,纳米粒中白藜芦醇的释放速度比原料的释放速度慢,有缓释作用。
Using corn protein as the wall material and resveratrol as the model drug, resveratrol-loaded zein nanoparticles were prepared by supercritical CO2 anti-solvent method. The effects of process parameters such as pressure, temperature and core mass ratio on resveratrol Effect of loading on nanoparticles. The samples were characterized by UV spectroscopy, scanning electron microscopy and X-ray diffraction analysis, and the release was studied. The results showed that the loading of resveratrol decreased with the increase of supercritical CO2 pressure. The resveratrol loading increased with the increase of temperature and core mass ratio. Corn protein and resveratrol formed Matrix structure, the nanoparticles are uniform spherical particles. Release experiments show that the release rate of resveratrol nanoparticles slow release rate than the raw material, slow release.