概述抗菌药应用范围广泛,是临床最常用药物之一,目前,仍以磺胺类和抗生素构成抗菌药的两大支柱。自1962年美国 Ste-rling—Winthrop 研究所 Lesher 发现第一个吡啶酮酸类抗菌药萘啶酸以来,这一领域的研究异常活跃,进展较快,到目前为止已有数百种该系列化合物合成,其中有20余种抗菌活性强的衍生物已用于临床或进入临床药理研究阶段,形成了有别于磺胺类和抗生素的一个新分支。根据 Overview Antibacterial applications a wide range of clinical is one of the most commonly used drugs, at present, still with sulfa and antibiotics constitute the two pillars of antimicrobial agents. Since the discovery of the first pyridinic acid antibiotic nalidixic acid by Lesher at the Ste-rling-Winthrop Institute in the United States in 1962, research in this area has been extremely active and has progressed so rapidly. Hundreds of these compounds have been reported so far Synthesis, of which more than 20 kinds of antibacterial activity derivatives have been used in clinical or clinical pharmacology research phase, the formation of a different from sulfonamides and antibiotics a new branch. according to