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目的了解抗60000 SSA(Sjogren syndrome Type A,SSA)抗体和抗52 000 SSA 抗体与系统性红斑狼疮(SLE)和干燥综合征(SS)的相关性。方法用免疫印迹(Western-blot)方法检测59例抗 SSA 抗体阳性患者血清,其中 SLE 44例,原发性 SS 15例。结果抗60000 SSA 抗体阳性率在SLE 及原发性 SS 间差异无统计学意义(P>0.05),但单独携带抗60000 SSA 抗体在 SLE 及原发性 SS间差异有统计学意义,SLE 患者单独抗60000 SSA 抗体阳性率为39.47%(15/38),原发性 SS 患者6.67%(1/15);抗52000 SSA 抗体阳性率在 SLE 及原发性 SS 间差异有统计学意义(P<0.05),原发性 SS 患者抗52000 SSA 抗体阳性率为93.33%(14/15),SLE 患者为60.53%(23/38)。抗60000和抗52000 SSA 抗体阳性率在继发性 SS 及原发性 SS 间差异均无统计学意义。结论原发性 SS 患者以抗52000 SSA 抗体为主,单独出现抗60000 SSA 抗体的几率极小。单独抗52000 SSA 抗体阳性可能与原发性 SS 有关,而不利于继发性 SS 的诊断。单独携带抗60000SSA 抗体则以 SLE 为主。
Objective To investigate the relationship between anti-Sjogren’s syndrome type A (SSA) antibodies and anti-52 000 SSA antibodies and systemic lupus erythematosus (SLE) and Sjogren’s syndrome (SS). Methods The serum of 59 anti-SSA antibody-positive patients were detected by Western-blot, including 44 cases of SLE and 15 cases of primary SS. Results There was no significant difference in the positive rate of anti-SOS antibody between SLE and primary SS (P> 0.05), but there was significant difference between SLE and primary SS alone The positive rates of anti-60000 SSA antibody were 39.47% (15/38) and those of primary SS were 6.67% (1/15). The positive rates of anti-52000 SSA antibody in SLE and primary SS were statistically significant (P < 0.05). The positive rate of anti-52000 SSA antibody in primary SS patients was 93.33% (14/15) and that in SLE patients was 60.53% (23/38). The positive rates of anti-60000 and anti-52000 SSA antibodies were not statistically different between secondary SS and primary SS. Conclusions Primary SS patients are resistant to anti-52000 SSA antibody and the probability of anti-SS antibody alone is very small. Anti-52000 SSA antibody alone may be associated with primary SS, but not conducive to the diagnosis of secondary SS. Anti-60000SSA antibody alone is the main SLE.