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本文对九四年四月至七月连续在我部进行亚冬眠脱毒治疗一百名病员(男六十八名,女三十二名)做了回顾性研究。有十二名病员(全部为男性)出现了肺源性呼吸困难,其主要表现为舌体后坠引起的吸入性呼吸困难和因吸入性肺炎导致的混合性呼吸困难。男女病员出现的肺源性呼吸困难的比例有高度显著的统计学差异。男性病员出现肺源性呼吸困难组的年龄(年),成瘾史(月),最大氯丙嗪和异丙嗪用量(毫克)分别为30.42±6.24,13.58±5.51,975.00±271.11;男性病员无呼吸困难组分别为27.00±4.96,11.48±5.96,1146.32±300.30,两组的年龄和最大日用药量有显著的统计学差异,出现呼吸困难组,年龄偏大,用药量较少。在亚冬眠脱毒治疗中,氯丙嗪,异丙嗪的用量是根据病人对药物的敏感程度决定的,出现肺源性呼吸困难的人都出现了过度镇静,他们大多是对亚冬眠疗法十分敏感的人。在海洛因脱毒治疗过程中,大多在四至六小时出现戒断反应的精神症状,在十八至三十六小时达到高潮,戒断反应迅速,不容易逐渐观察病人对亚冬眠疗法的敏感情况和耐受性,而由亚冬眠疗法的这一不良反应很容易造成死亡。我们认为,对亚冬眠疗法脱毒应持谨慎态度。
This retrospective study was conducted on 100 patients (68 men and 32 women) who underwent hypoglycemic treatment in our department from April to July 1994. Twelve patients (all men) developed pulmonary-derived dyspnea, which manifested as aspiration dyspnoea caused by the fall of the tongue and mixed dyspnea due to aspiration pneumonia. There was a highly significant statistical difference in the proportion of pulmonary-derived dyspnea between male and female patients. The age (years), history of addiction (months), the maximum amount of chlorpromazine and promethazine (mg) in male patients with pulmonary-derived dyspnea were 30.42 ± 6.24 and 13.58 ± 5, respectively. 51,975.00 ± 271.11; The male patients without respiratory distress group were 27.00 ± 4.96, 11.48 ± 5.96, 1146.32 ± 300.30, the age and the largest daily medication Significant statistical differences in the number of dyspnea group, older, less medication. In the Asian winter sleep detoxification treatment, chlorpromazine, promethazine dosage is based on the patient’s sensitivity to drugs, people with pulmonary dyspnea have appeared over-sedation, most of them are very sub-Asian hibernation therapy Sensitive people. In the course of heroin detoxification treatment, most of the psychiatric symptoms of withdrawal reaction occurred within four to six hours and culminated in eighteen to thirty-six hours. The withdrawal response was rapid and it was not easy to gradually observe the patient’s sensitivity to sub-hibernation therapy and Tolerance, while the adverse effects of Asiatic sleep therapy can easily lead to death. In our opinion, caution should be exercised on the detoxification of Asian Hibernation therapy.