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新生儿缺氧缺血性脑病(HIE)是新生儿期的常见疾病,多年来,多采取对症及支持等综合性治疗。自1996年2月以来,我们应用1.6-二磷酸果糖(FDP)治疗HIE48例,取得较好疗效,现报道如下。 一、病例选择:均为住院之足月新生儿,随机分为两组,治疗组48例,男25例,女23例,中度35例,重度13例。对照组48例,男30例,女18例,中度38例,重度10例。HIE的诊断符合1989年济南会议所制定的标准。并经头颅CT或B超检查所证实。 二、治疗方法:两组病例在入院后均给予常规支持治疗及对症处理,包括:吸氧、控制惊厥、纠正水、电解质及酸碱紊乱,降低颅内压。在此基础上,治疗组加用FDP200mg/kg·次静脉滴注,每日一次,连用7～10天。 三、疗效评价标准:以临床症状消失以及头颅B超
Neonatal hypoxic-ischemic encephalopathy (HIE) is a common disease in the neonatal period, over the years, to take more comprehensive treatment of symptomatic and supportive. Since February 1996, we apply the 1.6-diphosphate (FDP) treatment of 48 cases of HIE, and achieved good results, are reported below. First, the choice of cases: all hospitalized newborn infants were randomly divided into two groups, the treatment group of 48 patients, 25 males and 23 females, 35 cases of moderate and severe in 13 cases. The control group of 48 patients, 30 males and 18 females, moderate in 38 cases, severe in 10 cases. The diagnosis of HIE conformed to the standard set by Jinan Conference in 1989. And confirmed by skull CT or B-ultrasound. Second, the treatment: two groups of patients were given conventional supportive treatment and symptomatic treatment after admission, including: oxygen, control seizures, correct water, electrolyte and acid-base disorders, reduce intracranial pressure. On this basis, the treatment group plus FDP200mg / kg · intravenous infusion, once daily, once every 7 to 10 days. Third, the efficacy evaluation criteria: the disappearance of clinical symptoms and head B ultrasound