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目的探讨某院围手术期抗菌药物合理使用方案的可行性。方法对该院甲状腺、乳腺、腹外疝3种Ⅰ类切口患者围手术期抗菌药物使用的未干预前(2008年4—6月,非干预组,90例)和干预后(2010年4—6月,干预组,90例)情况进行对照研究。结果经干预后,上述Ⅰ类切口抗菌药物使用率和无指征预防用药率分别由干预前的100%、46.67%降至42.22%、8.89%;药物选择不合理率由干预前的66.67%降至1.11%;术前用药不合理率和术后用药不合理率分别由干预前的68.89%、68.89%降至7.78%、5.56%;平均抗菌药物费用由干预前的220.13元降至94.24元;上述指标两两比较,差异均有统计学意义(P<0.01)。结论该院所实施的干预措施对规范围手术期抗菌药物的合理使用起到了积极的作用,具有可行性和有效性。
Objective To explore the feasibility of rational use of perioperative antibacterials in a hospital. Methods The perioperative antibacterials in patients with type Ⅰ incision of thyroid, breast and abdominal hernia in this hospital before intervention (April-June 2008, non-intervention group, 90 cases) and after intervention (2010 4- June, intervention group, 90 cases) control study. Results After the intervention, the above-mentioned Ⅰ type incision antibiotic use rate and the non-indicatory prophylaxis rate decreased from 100% and 46.67% before intervention to 42.22% and 8.89% respectively; and the unreasonable rate of drug selection decreased from 66.67% before intervention To 1.11%. The unreasonable rates of preoperative medication and the unreasonable rates of postoperative medication decreased from 68.89% and 68.89% before intervention to 7.78% and 5.56% respectively. The average cost of antimicrobial drugs dropped from RMB 220.13 to RMB 94.24 before intervention. The above indicators each comparison, the difference was statistically significant (P <0.01). Conclusion The interventions implemented in this institute have played a positive role in regulating the rational use of perioperative antibiotics, which is feasible and effective.