泛发性硬皮病是以手指皮肤硬化和尖削以及指尖的小溃疡形成为特征的皮肤变化,但是如把这些病例作详细研究,可见除手指浮肿性硬化外,并有各种内脏病变和免疫异常,对肾上腺皮质激素有良好反应,Winkelmann(1971)命名为间质性硬皮病(MS)。作者报告8例,8例均为女性,年龄为27～53岁,8例均有皮肤的浮肿性硬化(腊肠样手指),肉眼及组织表现均显示皮肤硬化,除1例外, Pancreatic scleroderma is a change in the skin characterized by sclerosis and tapering of the fingers and the formation of small ulcers at the fingertips. However, as detailed studies of these cases show that in addition to edematous sclerosis of the fingers and various visceral lesions And immune abnormalities, have a good response to adrenocorticotropic hormone, Winkelmann (1971) named interstitial scleroderma (MS). The authors reported 8 cases, 8 cases were female, aged from 27 to 53 years old, 8 cases of edematous sclerosis (sausage-like fingers), macroscopic and histological findings showed skin sclerosis, except for 1 case,