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采用分析基因限制性内切酶片段长度多态性技术对96例冠心病患者和95例正常人载脂蛋白AI基因多态性进行检测,并对这一基因变化与高密度脂蛋白的关系进行研究。冠心病组中P_1P_2基因型血浆HDL和apoAI水平明显低于P_1P_1型,P_2等位基因与低α脂蛋白血症有较密切关系。携带P_2等位基因同时伴有血浆HDL和apoAI水平低下者,冠心病的发病率增高,并有早发心肌梗死的危险。
The polymorphism of apolipoprotein AI gene in 96 patients with coronary heart disease and 95 normal subjects was detected by analyzing gene fragment length polymorphism (RFLP). The relationship between this gene change and high density lipoprotein the study. The levels of HDL and apoAI in plasma of P 1 P 2 genotype in CHD group were significantly lower than those in P 1 P 1 type, and the P 2 allele had a close relationship with Hypothemia. Persons carrying the P 2 allele accompanied by low plasma HDL and apoAI levels have an increased prevalence of coronary heart disease and a risk of premature myocardial infarction.