侵袭性曲霉菌感染具有很高的死亡率,尤是在患白血病及粒细胞减少症的病人中已成为一个严重的临床问题。在最近Fraser等的报告中曲霉菌感染已成为美国第三种最常见的全身性真菌病,且其发病率增长最为迅速。这种增加反映了人口的老化及人们免疫抑制状态的增多。一些研究者认为在有住院的受损宿主中发生曲霉菌感染与通风不好有关。现在还没有手则来指导控制感染人员在更新或新建医院时去监测医院中空气的质量或检查空气处理系统。1977年秋季及冬季,我们发现北卡罗来纳纪念医院的住院患者呼吸样本中黄曲霉菌的检出率增多,遂进行一次流行病学调查,发现病 Invasive Aspergillus infections have a high mortality rate, and have become a serious clinical problem especially in patients with leukemia and neutropenia. As recently reported by Fraser et al., Aspergillus infection has become the third most common systemic fungal disease in the United States and its incidence has been increasing most rapidly. This increase reflects the aging of the population and an increase in the immunosuppressive state of the population. Some researchers believe that the occurrence of aspergillus infections in hospitalized damaged hosts is associated with poor ventilation. There are currently no hands to guide the infection control staff to monitor the quality of the air in the hospital or to check the air handling system when updating or building a new hospital. In the fall and winter of 1977, we found an increase in the rate of detection of Aspergillus flavus in the respiratory samples of hospitalized patients in North Carolina Memorial Hospital. We conducted an epidemiological survey and found that