BRAFn V600E突变是甲状腺乳头状癌（papillary thyroid cancer，PTC）较常见的基因突变，与PTC的发生、发展及预后存在相关性。TERT启动子突变在PTC中少见，但伴有其突变的PTC具有侵袭性更强、预后更差的特点。临床上，少部分PTC患者同时伴有BRAFn V600E和TERT启动子突变，本文从BRAFn V600E和TERT启动子共同突变与PTC的发生发展、临床诊断、手术策略、术后辅助治疗及预后等方面进行简要阐述。n “,”BRAFn V600E mutation is a common gene mutation in papillary thyroid carcinoma (PTC) , which is associated with the occurrence, development, and prognosis of PTC. TERT promoter mutations are rare in PTC, but PTC with its mutations is more aggressive and has a worse prognosis. Clinically, a small number of PTC patients have both BRAFn V600E mutation and TERT promoter mutations. This article provides a brief overview of the co-mutation of BRAFn V600E and TERT promoter and the occurrence and development, clinical diagnosis, surgical strategies, postoperative adjuvant treatment, and prognosis of PTC.n