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米非司酮是新型抗孕酮药物,主要通过与子宫蜕膜的孕酮受体结合阻断孕酮作用,引起流产。我们用米非司酮配伍米索前列醇(简称米索系PGE_1类似物)中止早孕,经335例观察,效果较好。 1.临床资料:本组年龄<40岁,停经≤49天,均确诊为宫腔内妊娠。为观察两药最低用量的最佳效果,将335例孕妇随机分两组用药,其年龄、身高、体重、孕前月经周期、经期及停经时间有可比性。 2.用药方法及结果:第1组155例,服用米非司酮25mg/12h,连用5次,第3天上午服米索600μg。第2组180例,服用米非司酮25mg/12h,连用6次,第4天上午服米索600μg。
Mifepristone is a new antiprogestin drug that blocks progesterone action by binding progesterone receptors to the uterine decidua that cause abortion. We use mifepristone combined with misoprostol (referred to as misoprostol PGE_1 analogues) termination of pregnancy, 335 cases observed, the effect is better. 1. Clinical data: The age of <40 years, menopause ≤ 49 days, were diagnosed as intrauterine pregnancy. In order to observe the best effect of the lowest dose of two drugs, 335 pregnant women were randomly divided into two groups, their age, height, weight, pre-pregnancy menstrual cycle, menstrual period and menopause time were comparable. 2. Medication methods and results: The first group of 155 cases, taking mifepristone 25mg / 12h, once every 5 times, the morning of the 3rd day of misoprostol 600μg. The second group of 180 cases, taking mifepristone 25mg / 12h, once every 6 times, the morning of the 4th day of misoprostol 600μg.