Neolithic site sections, natural sections and other proxy indicators like paleotrees and peat are collected for further understanding the environmental changes during the past 10,000 years in the Yangtze Delta region. The results indicate that cultural interruption in the Yangtze Delta was the result of water expansion induced by climatic changes like more precipitation. For fragile human mitigation to the natural hazards in the Neolithic cultural period, environmental changes usually exerted tremendous influences on human activities, havocking the human civilization, which is meaningful for human mitigation to natural hazards under the present global warming. At the same time, some uncertainties in reconstruction of paleo-environmental changes were discussed in the text.