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本研究的目的是建立一种可供于影像学研究的大鼠肝炎性假瘤(IPL)模型,并研究其影像学的特征。所用的材料和方法是将弗氏佐剂01ml/只作大鼠深部注射,10天后观察大鼠病灶的影像学特征;并取标本做病理检查。结果发现了IPL发生率为90%,大小分别是032±018cm。IPL的影像学特征表现为强回声结节;CT平扫为低度圆形影,无强化或仅轻微强化;T1WI则呈等或高信号,T2WI为略高信号。病理学证实局部肝组织片状坏死并有纤维组织增生及炎细胞浸润。结论是本文研究的大鼠肝炎性假瘤模型具有易建立、容易复制、成功率高、制备周期短和影像学的表现较典型等特点,对今后探讨大鼠肝炎性假瘤的形成机制及影像学特征将发挥积极作用
The purpose of this study was to establish a rat model of hepatitic pseudotumor (IPL) for imaging studies and to study its imaging characteristics. The materials and methods used were deep injections of Freund’s adjuvant 01ml/body alone. After 10 days, the imaging features of the rat lesions were observed; specimens were taken for pathological examination. It was found that the incidence of IPL was 90% and the size was 032±018cm. The imaging features of IPL showed strong echogenic nodules; CT plain scan had low circularity, no enhancement or only slight enhancement; T1WI showed equal or high signal, and T2WI had slightly higher signal. Pathology confirmed local liver necrosis and fibrous tissue proliferation and inflammatory cell infiltration. The conclusion is that the rat model of hepatic inflammatory pseudotumor studied in this article has the characteristics of easy establishment, easy replication, high success rate, short preparation cycle, and typical imaging findings. Learning characteristics will play an active role