目的 :研究尼美舒利分散片在人体内的药物动力学 ,并对其生物等效性进行评价。方法 :10名健康男性志愿者随机交叉口服单剂量 (2 0 0mg)分散片或普通片。采用HPLC测定血浆中的血药浓度。结果 :血药浓度 -时间曲线符合一室模型 ;尼美舒利分散片的相对生物利用度为 96 %。结论 :尼美舒利分散片和普通片药动学性质相似 ,两者具有生物等效性 Objective: To study the pharmacokinetics of nimesulide dispersible tablets in human and evaluate its bioequivalence. Methods: Ten healthy male volunteers were randomized to receive a single dose (200 mg) of dispersible tablets or plain tablets. Plasma concentrations of plasma were determined by HPLC. Results: The plasma concentration-time curve was consistent with a one-compartment model. The relative bioavailability of nimesulide dispersible tablets was 96%. Conclusion: Nimesulide dispersible tablets and common tablets have similar pharmacokinetic properties, both of which are bioequivalent