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目的探讨牙源性鳞状细胞瘤(SOT)的临床表现、X线特点及病理形态学特征。方法对1例SOT的形态学及免疫组化特点进行分析,复习相关文献,讨论其诊断与鉴别诊断。结果 SOT的主要形态学表现为,成熟的纤维结缔组织内可见散在分布的分化良好的鳞状上皮岛,肿瘤性上皮团块周边部的细胞呈扁平或立方状,有的上皮团中央可见囊性变及角化物,偶见成层钙化。免疫组化:肿瘤细胞CK、CK5和p63(+),p53(-),Ki-67阳性指数<3%。结论 SOT是一种罕见的良性牙源性上皮性肿瘤,特征性的X线表现和病理学特点是其诊断依据,需要与成釉细胞瘤、高分化鳞状细胞癌、牙源性钙化上皮瘤和牙源性角化囊肿相鉴别。
Objective To investigate the clinical manifestations, X-ray features and pathomorphological features of odontogenic Squamous Cell Tumors (SOT). Methods The morphological and immunohistochemical features of one case of SOT were analyzed, and relevant literature was reviewed to discuss its diagnosis and differential diagnosis. Results The main morphological features of SOT were scattered well-differentiated squamous island in mature fibrous connective tissue, flat or cuboidal cells in the periphery of tumorous epithelial mass, cysticity in some of the epithelial mass Change and keratosis, occasionally stratified calcification. Immunohistochemistry: CK, CK5 and p63 (+), p53 (-), Ki-67 positive index of tumor cells <3%. Conclusions SOT is a rare benign odontogenic epithelial tumor. The characteristic radiological and pathological features of SOT are its diagnostic basis. It needs to be associated with ameloblastoma, highly differentiated squamous cell carcinoma, odontogenic calcified epithelioma And odontogenic keratocyst differentiate.