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目的讨论卡培他滨单药化疗对老年晚期胃癌的近期疗效。方法 16例晚期胃癌患者采用卡培他滨单药化疗方案共38周期。结果完全缓解3例,部分缓解8例,无变化4例,病情进展1例,总有效率为68.75%;中位缓解期6个月,中位生存期8个月,1年生存期占45.00%,临床受益共15例(93.75%);不良反应轻,对症治疗后均好转,无死亡病例发生,无患者因不良反应中止治疗。结论卡培他滨单药化疗对老年晚期胃癌的近期疗效较好,使用方便,不良反应轻,老年患者能够接受,可作为经济状况良好的老年晚期胃癌患者的一线治疗方案,可在更多的患者中应用,以进一步探讨其疗效。
Objective To discuss the short-term effect of capecitabine monotherapy on advanced gastric cancer. Methods Sixteen patients with advanced gastric cancer received capecitabine monotherapy for a total of 38 cycles. The results of complete remission in 3 cases, partial remission in 8 cases, no change in 4 cases, 1 case of progression, the total effective rate was 68.75%; the median remission of 6 months, the median survival of 8 months, 1-year survival of 45.00 %, Clinical benefit of a total of 15 cases (93.75%); adverse reactions, symptomatic treatment were improved, no deaths occurred, no patient discontinued treatment due to adverse reactions. Conclusion Capecitabine monotherapy for advanced gastric cancer in advanced efficacy, ease of use, mild adverse reactions, elderly patients can be accepted as a good first-line treatment of elderly patients with advanced gastric cancer in the economy, available in more Patients in the application to further explore its efficacy.