AIM:To evaluate the detectability of gallbladder stones by dual-energy spectral computed tomography(CT) imaging.METHODS:Totally 217 patients with surgically confirmed gallbladder stones were retrospectively analyzed who underwent single-source dual-energy CT scanning from August 2011 to December 2013. Polychromatic images were acquired. And post-processing software was used to reconstruct monochromatic(40 ke V and 140 ke V) images,and calcium-lipid pair-wise base substance was selected to acquire calcium base images and lipid base images. The above 5 groups of images were evaluated by two radiologists separately with 10-year experience in CT image reading. In the 5 groups of images,the cases in the positive group and negative group were counted and then the detection rate was calculated. The inter-observer agreement on the scoring results was analyzed by Kappa test,and the scoring results were analyzed by Wilcoxon test,with P < 0.05 indicating that the difference was statistically significant. The stone detection results of the 5 groups of images were analyzed by χ2 test.RESULTS:There was good inter-observer agreement(k = 0.772). In 217 patients with gallbladder stones,there was a statistically significant difference in stone visualization between spectral images(40 ke V,140 ke V,calcium base and lipid base images) and polychromatic images(P < 0.05). 40 ke V monochromatic images were better than 140 ke V monochromatic images(4.90 ± 0.35 vs 4.53 ± 1.15,P < 0.05),and calcium base images were superior to lipid base images(4.91 ± 0.43 vs 4.77 ± 0.63,P < 0.05),but there was no statisticallysignificant difference between 40 ke V monochromatic images and calcium base images(4.90 ± 0.35 vs 4.91 ± 0.43,P > 0.05). In 217 gallbladder stone patients,there were 21,3,28,5 and 12 negative stone cases in polychromatic images,40 ke V images,140 ke V images,calcium base images and lipid base images,respectively,and the differences among the five groups were statistically significant(P < 0.05).CONCLUSION:Monochromatic images and base substance images have a good clinical prospect in the iso-density stone detection. AIM: To evaluate the detectability of gallbladder stones by dual-energy spectral computed tomography (CT) imaging. METHODS: Totally 217 patients with surgically confirmed gallbladder stones were retrospectively analyzed who underwent single-source dual-energy CT scanning from August 2011 to December 2013 Polychromatic images were acquired. And post-processing software was used to reconstruct monochromatic (40 ke V and 140 ke V) images, and calcium-lipid pair-wise base substance was selected to acquire calcium base images and lipid base images. 5 the groups of images were evaluated by two radiologists separately with 10-year experience in CT image reading. In the 5 groups of images, the cases in the positive group and negative group were counted and then the detection rate was calculated. The inter-observer agreement on the scoring results were analyzed by Kappa test, and the scoring results were analyzed by Wilcoxon test, with P <0.05 indicating that the difference was statistically sign ificant. The stone detection results of the 5 groups of images were analyzed by χ2 test. RESULTS: There was good inter-observer agreement (k = 0.772). In 217 patients with gallbladder stones, there was a significant difference in stone visualization between (40 ke V, 140 ke V, calcium base and lipid base images) and polychromatic images (P <0.05) .40 ke V monochromatic images were better than 140 ke V monochromatic images (4.90 ± 0.35 vs 4.53 ± 1.15, P (4.91 ± 0.43 vs. 4.77 ± 0.63, P <0.05), but there was no significant difference between 40 ke V monochromatic images and calcium base images (4.90 ± 0.35 vs 4.91 ± 0.43, P> 0.05). In 217 gallbladder stone patients, there were 21, 28, and 12 negative stone cases in polychromatic images, 40 ke V images, 140 ke V images, calcium base images and lipid base images, respectively, and the differences among the five groups were patrol signi ficant (P <0.05) .CONCLUSION: Monochromatic images and base substance images have a good clinical prospect in the iso-density stone detection.