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目的 :为了探讨苯海索对蛛网膜下腔出血(SAH)后脑血管痉挛及自由基损伤的预防作用。方法 :采用大鼠蛛网膜下腔出血模型 ,放射性生物微球法测定SAH后脑皮质局部血流量 (rCBF) ,分别采用肾上腺素自氧化法和硫代巴比妥酸法检测脑皮质超氧化物歧化酶 (SOD)和脂质过氧化物 (LPO)的水平。结果 :SAH后 4 8h时脑皮质血流量降低 57.7% (P <0 .0 1) ,LPO含量显著升高 (P <0 .0 1) ,SOD活力明显降低 (P <0 .0 5) ;苯海索可显著增加SAH后脑皮质血流量 (P <0 .0 1)和减少LPO的生成 (P<0 .0 1)。结论 :苯海索可有效防止SAH后脑血管痉挛的发生 ,增加rCBF ,并减轻脑皮质的自由基损伤。
Objective: To investigate the preventive effect of trihexyphenidyl on cerebral vasospasm and free radical injury after subarachnoid hemorrhage (SAH). Methods: The subarachnoid hemorrhage model was established in rats and the rCBF was measured by radioactive biological microsphere method. The cortical superoxide dismutase Enzyme (SOD) and lipid peroxidation (LPO) levels. Results: Cerebral cortical blood flow decreased by 57.7% (P <0.01) at 48 h after SAH, LPO content increased significantly (P <0.01) and SOD activity decreased significantly (P <0.05). Phenoxyethanol significantly increased cerebral cortex blood flow (P <0.01) and decreased LPO production (P <0.01) after SAH. Conclusion: Phenoxyethanol can effectively prevent the occurrence of cerebral vasospasm after SAH, increase rCBF, and reduce the free radical damage of cerebral cortex.