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近年来,随着药物种类的不断增多,药物引起的黄疸发生率也相应增加。因此,药物与黄疸的关系日益受到重视。一、药物性肝细胞损害导致的黄疸 1985年荷兰药物副作用监测中心Stricker统计,对肝脏可能有损害作用的药物约600余种。药物性肝病大都有黄疸表现。药物引起的肝细胞损害有两种因素: (1)药物本身毒性:其特点是肝损害与药物的剂量、疗程有关,在动物实验中能复制。如四氯化碳、锑剂、无机磷、四环素、硫氧嘧啶、利福平及酒石酸锑钾等。近年来,许多研究证明药物性肝损伤与脂质过氧化有密切关系,如扑热息痛、阿斯匹林、维生素K3及氟烷等所致肝损伤并伴黄疸出现均与脂质过氧
In recent years, with the increasing types of drugs, the incidence of jaundice caused by drugs also increased accordingly. Therefore, the relationship between drugs and jaundice is receiving more and more attention. First, drug-induced liver cell damage caused by jaundice 1985 Netherlands Drug Side Effects Monitoring Center Stricker statistics, the liver may have damaging effects of about 600 kinds of drugs. Most drug-induced liver disease jaundice performance. Drug-induced liver cell damage has two factors: (1) the drug itself toxicity: It is characterized by liver damage and drug dose, treatment-related, in animal experiments can replicate. Such as carbon tetrachloride, antimony agent, inorganic phosphorus, tetracycline, thiouracil, rifampicin and antimony potassium tartrate and so on. In recent years, many studies have shown that drug-induced liver injury and lipid peroxidation are closely related, such as paracetamol, aspirin, vitamin K3 and halothane caused by liver damage and jaundice appeared with lipid peroxidation