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α_2-巨球蛋白(α2M)是人血浆中主要的蛋白酶抑制因子,它能抑制范围很广的人及细菌内肽酶。尽管目前对其分子结构和抑制功能有所了解,但是其体内功能以及在人类疾病致病机制中可能的作用还不为人知。我们知道,另外一种血浆主要蛋白酶抑制因子α_1抗胰蛋白酶(α1AT)的遗传缺陷,
Alpha-2-macroglobulin (α2M) is a major protease inhibitor in human plasma that inhibits a wide range of human and bacterial endopeptidases. Despite the current understanding of its molecular structure and inhibitory function, its function in vivo and its possible role in the pathogenesis of human disease are unknown. We know that another genetic defect in plasma major protease inhibitor alpha-1 antitrypsin (alpha1AT)