论文部分内容阅读
本文报告10例急性非淋巴细胞性白血病(ANLL)的临床病理学研究,从白血病原始细胞的形态学、细胞化学及超微结构等方面均极相似,似乎构成一种 ANLL 的亚型。常规血液及骨髓涂片:发现原始细胞的体积较大(18～25μ);胞浆丰富呈兰灰色,具有细小空泡及大量散在的嗜亚尼兰颗粒,未发现 Auer 小体,偶见胞浆伸长;核呈圆形或卵圆形,居中或偏心,染色质呈网状,通常见1～4个浅兰色的核仁。细胞化学方面:原始细胞非特异性脂酶(NSE)呈强阳性,经氟化钠孵育时,10例中有9例酶的活性完全被抑制,仅1例从强阳性降至弱阳性;酸性磷酸酶除1例因髓片已贮存8年而呈阴性反应
This article reports 10 cases of acute non-lymphocytic leukemia (ANLL) of the clinicopathological studies, from leukemia blast cells morphological, cytochemical and ultrastructural aspects are very similar, it seems to constitute a subtype of ANLL. Conventional blood and bone marrow smear: found that the original cells larger (18 ~ 25μ); rich cytoplasm was blue-gray, with small vacuoles and a large number of diffused ametrine particles, found no Auer bodies, occasional cells Pulp elongation; nucleus was round or oval, central or eccentric, chromatin was reticular, usually see 1 to 4 light blue kernels. In terms of cytochemistry, the activity of NSE was strongly positive. When incubated with sodium fluoride, the activity of 9 of the 10 patients was completely inhibited, and only one of them was reduced from strong positive to weak positive. Acidic phosphoric acid In addition to a case of enzyme for 8 years has been stored for a negative reaction