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血清丙型肝炎病毒(HCV)抗体检测表明,美国输血后非甲非乙型肝炎中90％是由HCV感染引起。急性HCV感染常无特异性临床表现,约三分之一患者可在输血后出现黄疸,约60％输血后非甲非乙型肝炎患者转氨酶可持续升高6个月或更长。在一项研究,输血后HCV抗体阳性并转氨酶升高者,若血清中检出HCV RNA,则证实HCV是慢性肝炎的主要原因。本文对131例输血相关性丙型肝炎的临床转归作一随访研究。 作者对某医院肝病中心自1980年2月至1994年6月收治的213例有输血史HCV抗体阳性慢性肝炎患者进行评估,将其中82例有多
Serum Hepatitis C virus (HCV) antibody tests showed that 90% of non-A, non-B hepatitis cases in the United States were caused by HCV infection. Acute HCV infection often has no specific clinical manifestations. About one-third of patients may have jaundice after blood transfusion, and about 60% of transfusions in patients with non-A, non-B hepatitis may continue to rise for 6 months or longer. In one study, HCV antibodies were positive after transfusion with elevated transaminases, and HCV RNA was the major cause of chronic hepatitis B if HCV RNA was detected in serum. In this paper, 131 cases of blood transfusion-related hepatitis C clinical outcome for a follow-up study. The authors evaluated 213 patients with HCV-positive chronic hepatitis who had a transfusion history from February 1980 to June 1994 at a liver cirrhosis center in a hospital, of which 82 were more