论文部分内容阅读
一、吡美诺(Pirmenol)本药为1977年美国合成的吡啶甲醇衍生物,其化学结构、电生理学特征与双异丙吡胺类似,抗胆硷作用比双异丙吡胺弱,肝首次通过少,生物利用度约87%,生物学半衰期长达7～9小时。故每日2次给药为其特征。二、pentisomide本药为法国开发的Ⅰ类药物。其化学结构类似双异丙吡胺,而电生理学特征各异。本药具有缩短动作电位持续时间、缩短有效不应期(正常化)和缩短延长的QT 间期等特征。从使用依赖性抑制分类来看为缓慢
First, the Pirmenol (Pirmenol) The drug for the United States in 1977 pyridine pyridine methanol derivatives, its chemical structure, electrophysiological characteristics and bipyridamides similar anti-cholinergic effect than double-dipyridyl amine weak, liver for the first time Through less, about 87% bioavailability, biological half-life of up to 7 to 9 hours. Therefore, twice daily administration as its characteristics. Second, pentisomide The drug developed for the French class Ⅰ drugs. Its chemical structure is similar to that of dipyridamole, but its electrophysiological characteristics are different. The drug has shortened action potential duration, shorten the effective refractory period (normalization) and shorten the extension of the QT interval and other characteristics. The use of dependency suppression classification is slow