以N-磷酰氨基酸为载体而形成的氮芥磷酰胺衍生物,可能具有较好的抗肿瘤专属性。双-(β-氯乙基)氨基磷酰二氯(Ⅰ)与二当量的甘、丙、缬、亮、笨丙、天冬及谷氨酸乙酯(Ⅱ)缩合,生成相应的N,N-双-(β-氯乙基)-N′,N″-二-(乙氧羰甲基)磷三酰胺衍生物(Ⅲ);与当量的丝氨酸乙酯(Ⅹ)缩合时生成环状衍生物,2-双-(β-氯乙基)氨基-4-乙氧羟基-四氢-1,2,3-氧膦氮茂,2-氧化物(Ⅺ)。这类化合物经动物实验有显著的抗肿瘤活性。 The nitrogen mustard phosphoramidite derivatives formed by using N-phosphoryl amino acid as a carrier may have better anti-tumor specificity. The condensation of bis- (β-chloroethyl) amino phosphoryl dichloride (Ⅰ) with two equivalents of glycerol, propionyl, vallen, light, stupid, asparagus and ethyl glutamate (Ⅱ) yields the corresponding N, N-bis- (β-chloroethyl) -N ’, N "-di- (ethoxycarbonylmethyl) phosphityl triamide derivative (III); when cyclized with an equivalent amount of serine ethyl ester Derivatives of 2-bis- (β-chloroethyl) amino-4-ethoxyhydroxy-tetrahydro-1,2,3-oxophosphorane, 2-oxide (XI) Have significant antitumor activity.