白细胞介素-1(interleukin-1,IL-1)系统分子广泛分布于中枢神经系统。中枢IL-1具有极其丰富的生物学功能,作为经典炎性细胞因子,在多种生理、病理生理过程中起重要作用。近几年来,中枢IL-1的应激介质作用备受关注。本文综述了中枢IL-1在应激反应中作用的最新进展,包括应激对中枢IL-1系统的影响,中枢IL-1对应激反应的启动和介导作用;参与中枢IL-1应激介导作用的神经环路和细胞信号转导通路,以及中枢IL-1对应激时脑高级功能和行为反应的影响。 Interleukin-1 (IL-1) system molecules are widely distributed in the central nervous system. Central IL-1 has a very rich biological function, as a classic inflammatory cytokines, in a variety of physiological and pathophysiological processes play an important role. In recent years, the role of stress mediator of central IL-1 attracts much attention. This review summarizes recent advances in the role of central IL-1 in stress response, including the effects of stress on the central IL-1 system, the initiation and mediation of central IL-1 responses, the involvement of central IL-1 stress Mediated neural circuits and cell signal transduction pathways, as well as the effects of central IL-1 on brain function and behavioral responses to stress.