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目的通过对宜兴地区40岁以上人群的高血压患病情况进行流行病学调查,探讨C-反应蛋白(CRP)与血压水平及高血压的关系。方法采用分层整群抽样的方法,选择宜兴市徐舍镇5个村40岁以上的人群2 400人作为研究对象,采用统一的流行病学调查表收集基本人口学资料、生活习惯、环境因素暴露史和个人疾病史等相关信息,同时测量血压、身高、体重和腰围,检测血糖、血脂和CRP等生化指标。结果 (1)实际参与调查人数为1 899人,应答率为79.13%,收集有效问卷1 897份,有效率为99.89%;(2)线性相关分析显示,CRP与收缩压、舒张压之间无统计学联系(r=-0.023,P=0.316;r=-0.027,P=0.246);t检验结果显示,CRP升高组(≥3.23 mg/L)与CRP正常组(<3.23 mg/L)间收缩压和舒张压水平亦无显著差异(t=1.224,P=0.221;t=0.266,P=0.790)。进一步进行Logistic回归分析发现,校正年龄后,在体质指数正常(18.5～23.9 kg/m2)人群中,CRP与高血压关联的OR(95%CI)为1.509(0.981～2.230)。结论 CRP升高与收缩压、舒张压无线性关联,而体质指数正常的人群中,CRP升高可能是高血压的独立危险因素。
Objective To investigate the relationship between C-reactive protein (CRP) and blood pressure and hypertension by investigating the prevalence of hypertension in people over the age of 40 in Yixing district. Methods A stratified cluster sampling method was used to select 2 400 people over the age of 40 from 5 villages in Xu She Town, Yixing City as the research object. A unified epidemiological questionnaire was used to collect basic demographic data, living habits and environmental factors Exposure history and history of personal diseases and other related information, while measuring blood pressure, height, weight and waist circumference, blood glucose, blood lipids and CRP and other biochemical indicators. Results (1) The number of people actually participating in the survey was 1 899, the response rate was 79.13%, and 1 897 valid questionnaires were collected, with an effective rate of 99.89%. (2) Linear correlation analysis showed that there was no correlation between CRP and systolic and diastolic blood pressure (R = -0.023, P = 0.316; r = -0.027, P = 0.246). The results of t test showed that CRP elevated group (3.23 mg / L) and CRP normal group (3.23 mg / L) There was also no significant difference in systolic and diastolic blood pressure (t = 1.224, P = 0.221; t = 0.266, P = 0.790). Further logistic regression analysis showed that the OR (95% CI) of CRP and hypertension was 1.509 (0.981-2.230) after correction for age in normal body mass index (18.5-23.9 kg / m2) population. Conclusions The elevated CRP is not associated with systolic and diastolic pressure. However, elevated CRP may be an independent risk factor for hypertension in normal body mass index.