论文部分内容阅读
目的观察咖啡酸苯乙酯联合地塞米松对肺纤维化模型的治疗效果,为临床治疗肺纤维化提供新的有效策略。方法采取常规药物地塞米松与抗氧化剂单独或联合对动物模型进行干预治疗,观察实验性治疗效果,包括病理指标、羟脯氨酸含量、氧化应激指标变化。结果与对照相比,各处理组动物的肺组织纤维化程度均有加重(P<0.05),而14d时与BLM组相比,各治疗组程度均较弱,DEX与CAPE联合治疗组程度最弱(P<0.05)。各处理组羟脯氨酸含量均增加,14d时DEX组与联合治疗组的肺羟脯氨酸明显少于BLM组(P<0.05)。对肺组织氧化应激相关的指标观察发现,治疗组在不同时间点都不同程度地改善氧化应激状态,联合治疗的作用强于单独治疗。结论抗氧化剂CAPE可以对大鼠肺纤维化模型产生一定治疗效果,为探索肺纤维化疾病的抗氧化治疗提供了重要线索。
Objective To observe the therapeutic effect of caffeic acid phenethyl ester and dexamethasone on pulmonary fibrosis model and provide a new effective strategy for clinical treatment of pulmonary fibrosis. Methods The conventional drug dexamethasone and antioxidants were used alone or in combination to treat animal models. The experimental therapeutic effects including pathological indexes, hydroxyproline content and oxidative stress indexes were observed. Results Compared with the control group, the lung tissue fibrosis in all treatment groups was aggravated (P <0.05), while the levels in the treatment group were weaker than those in the BLM group on the 14th day. The extent of the combination of DEX and CAPE was the highest Weak (P <0.05). The levels of hydroxyproline increased in all treatment groups, and the levels of hydroxyproline in DEX group and combined treatment group were significantly less than those in BLM group on the 14th day (P <0.05). Oxygen stress-related indicators of lung tissue observed found that the treatment group at different time points to varying degrees, to improve oxidative stress, combined treatment is stronger than the single treatment. Conclusion Antioxidant CAPE can produce certain therapeutic effect on rat pulmonary fibrosis model and provide important clues for exploring anti-oxidation therapy of pulmonary fibrosis.