以α -卤代酮和二甲胺为原料 ,用常压法合成 1-对氟苯基 -2 -二甲氨基 -1-丁酮。探讨了合成反应的条件 ,当以α -溴代酮为原料 ,二甲胺 /α -溴代酮 (摩尔比 )为 4 / 1,在溶剂存在下 ,温度为 0± 2℃ ,反应 12h ,产率达92 5% ,并对产物的结构进行了表征 Using α - haloketone and dimethylamine as raw materials, 1 - p - fluorophenyl - 2 - dimethylamino - 1 - butanone was synthesized by atmospheric pressure method. The conditions for the synthesis were discussed. When α - bromoketone was used as raw material, the molar ratio of dimethylamine / α - bromoketone was 4/1, the reaction temperature was 0 ± 2 ℃, The yield of 92 5%, and the structure of the product was characterized