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目的 :探讨绞股蓝对慢性肾功能不全 (CRI)血浆内皮素、血脂及肾功能的影响。方法 :将 138例CRI患者随机分成治疗组 ( 6 9例 )和对照组 ( 6 9例 ) ,对照组采用常规治疗方法 ,治疗组在常规治疗的同时 ,加用绞股蓝治疗 ,两组疗程均为 8周。对比观测治疗前后血浆内皮素 (ET)、血脂及肾功能变化。结果 :治疗组治疗后高密度脂蛋白 (HDL)、内生肌酐清除率 (Ccr)较对照组明显升高 (P <0 .0 1,P <0 .0 5 ) ,而血浆内皮素、甘油三酯、低密度脂蛋白 (LDL)、血尿素氮 (Bun)和血肌酐 (Scr)较对照组明显降低 (P <0 .0 5 ,P <0 .0 1,P <0 .0 5 )。结论 :绞股蓝具有拮抗内皮素、降血脂及改善肾功能的作用。
Objective: To investigate the effect of Gynostemma on plasma endothelin, lipid and renal function in patients with chronic renal insufficiency (CRI). METHODS: 138 patients with CRI were randomly divided into treatment group (69 cases) and control group (69 cases). The control group was treated with routine treatment. The treatment group was treated with gynostemma at the same time as conventional treatment. The treatment course was both 8 weeks. The changes of plasma endothelin (ET), lipids and renal function before and after treatment were compared. Results: After treatment, the high-density lipoprotein (HDL) and endogenous creatinine clearance (Ccr) were significantly higher in the treatment group than in the control group (P < 0.01, P <0.05), while plasma endothelin and glycerol Triglycerides, low-density lipoprotein (LDL), blood urea nitrogen (Bun), and serum creatinine (Scr) were significantly lower than those in the control group (P <0.05, P <0.01, P <0.05). . Conclusion : Gynostemma pentaphyllum has the effects of antagonizing endothelin, reducing blood fat and improving renal function.