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目的:探讨纳米脂肪移植联合COn 2点阵激光治疗面部凹陷性瘢痕的临床效果。n 方法:回顾性分析2016年1月至2018年6月浙江大学医学院附属第二医院及其余杭院区收治的面部凹陷性瘢痕患者的临床资料。进行1个周期的治疗：首先进行1次自体纳米脂肪移植，用26 G针头对凹陷性瘢痕进行皮下分离，将自体纳米脂肪注射至凹陷性瘢痕组织内，注射量为0.5～1.0 ml/cmn 2；3个月后进行COn 2点阵激光治疗，共2次，间隔3个月。治疗前和治疗后6个月，患者和医生通过患者和观察者瘢痕评估量表(POSAS)对瘢痕各指标分别进行评分，单项总分为1～10分，分数越高表示瘢痕越严重。根据患者及医生的POSAS总评分，对凹陷性瘢痕改善程度进行分级和疗效评价：一级，总分减小≤5分，为无效；二级，总分减小>5分且≤10分，为好转；三级，总分减小>10分且≤20分，为有效；四级，总分减小>20分，为显效。随访时观察并发症发生情况。采用SPSS 23.0对治疗前、后数据进行配对n t检验，n P 10 points and ≤ 20 points; grade 4, markedly effective, total score reduction> 20 points. Using SPSS 23.0 to don t-test on the data before and after treatment. n P<0.05 indicates that the difference is statistically significant.n Results:A total of 27 patients were enrolled, including 16 males and 11 females, aged (29.1±7.9) years old. Before and after six months of treatment, the difference between the scores of the patients on all indicators of scar was statistically significant (n P<0.05); the difference between the doctor’s scores was statistically significant (n P<0.01). The total scores of post-total POSAS were (43.7±10.8) and (23.3±3.2) points respectively, the difference was statistically significant (n P<0.01). After six months of treatment, the degree of pain, itching, color, hardness, thickness (depression), elasticity, tension of the depressed scar were significantly improved. Among them, there was 1 case of second-level improvement, 14 cases of third-level improvement, and 12 cases of fourth-level improvement. The total effective rate reached 96.3% (26/27). None of the 27 patients had lumps or cord-like indurations on the filling parts of the face. No embolism, infection, hematoma and other complications occurred after nanofat transplantation in all patients. Skin flushing, burning, edema, pain and other symptoms occurred early after the fractional COn 2 laser treatment, and no hyperpigmentation occurred in the 6-month follow-up after a treatment cycle.n Conclusions:The combination of nanofat transplantation technology and carbon dioxide fractional COn 2 laser can produce a significant effect on improving depressed scar, reducing treatment period, rendering a simple operation with few complications.n