论文部分内容阅读
目的:比较不同纵隔淋巴结清除范围对Ⅰ期非小细胞肺癌(NSCLC)患者生存的影响。方法:回顾性分析97例手术切除的Ⅰ期NSCLC患者临床资料,比较纵隔淋巴结清除术(SML)与纵隔淋巴结采样术(LS)对于患者生存的影响。用Kaplan-Meier曲线及Log-rank检验进行生存分析和比较,并用Cox多因素回归分析了解与生存相关的因素。结果:行SML的患者(n=28)5年生存率优于行LS的患者(n=69;84.36%vs68.54%;P=0.025)。Cox多因素分析提示,行SML是影响患者预后的因素。结论:肺叶切除加上SML能提高Ⅰ期NSCLC患者的长期生存率,可列为NSCLC的规范性术式。
Objective: To compare the effects of different mediastinal lymph node dissection on the survival of patients with stage Ⅰ non-small cell lung cancer (NSCLC). Methods: The clinical data of 97 patients with stage Ⅰ NSCLC surgically resected were retrospectively analyzed. The effects of mediastinal lymphadenectomy (SML) and mediastinal lymph node sampling (LS) on the patients’ survival were compared. Survival analysis and comparison were performed using Kaplan-Meier curves and Log-rank test, and Cox regression analysis was used to understand survival-related factors. Results: The 5-year survival rate of patients with SML (n = 28) was superior to those with LS (n = 69; 84.36% vs68.54%; P = 0.025). Cox multivariate analysis suggested that the line of SML affect the prognosis of patients. Conclusions: Lectomy combined with SML can improve the long-term survival rate of patients with stage I NSCLC and can be used as a normative procedure for NSCLC.