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目的 探讨人类增殖性肾炎（ＰＧＮ） 肾小球中胰岛素样生长因子１（ＩＧＦ１） 的表达及其意义。方法 采用原位杂交、免疫组织化学方法检测肾活检组织中ＩＧＦ１ ｍＲＮＡ及其蛋白质表达，并分析其与患者肾小球内细胞外基质（ＥＣＭ） 增生的关系。结果 增殖性肾炎组中ＩＧＦ１ 的表达水平显著高于非增殖性肾炎组和正常组（ Ｐ＜０－０１），ＩＧＦ１ 表达水平与ＥＣＭ 增生程度呈正相关。结论 肾小球局部ＩＧＦ１ 基因异常表达参与了ＰＧＮ的发病机制。
Objective To investigate the expression of insulin-like growth factor-1 (IGF-1) in glomeruli of human proliferative glomerulonephritis (PGN) and its significance. Methods The expression of IGF1 mRNA and protein in renal biopsies was detected by in situ hybridization and immunohistochemistry. The relationship between the expression of IGF1 mRNA and protein in glomerular extracellular matrix (ECM) was analyzed. Results The expression of IGF-1 in proliferative glomerulonephritis group was significantly higher than that in non-proliferative glomerulonephritis group and normal group (P <0-01). The expression of IGF-1 was positively correlated with the degree of ECM hyperplasia. Conclusion The abnormal expression of glomerular IGF-1 gene is involved in the pathogenesis of PGN.